【学位・学歴】
昭和薬科大学 薬学部 薬学科 卒業
昭和薬科大学 大学院 薬学研究科 薬品分析学専攻 修了　修士（薬学）
静岡県立大学 大学院 薬学学研究科 製薬学専攻 修了　博士（薬学）

【職歴】
ワシントン大学 セントルイス校 博士研究員
久留米大学 医学部 助手
久留米大学 医学部 講師
青森大学 薬学部 准教授
青森大学 薬学部 教授

薬剤師

糖鎖生物学、細胞生物学、神経化学

細胞機能を制御する糖鎖分子に関する研究
抗炎症活性を持つ分子の探索とその応用

【researchmap】
https://researchmap.jp/sotogaku

【著書】

• 基礎から学ぶ物理薬剤学・製剤学 南江堂
• 臨床医として知っておきたいミネラルの知識　東京医学社
• ストレス科学事典　実務教育出版社
• Metal Ions in Biology and Medicine　John Libbey Eurotext

【論文】

• Sotogaku N, Nishi A: Chondroitin sulfate E regulates neuronal adhesion by promoting actin polymerization through activation on the VEGF receptor/Akt/GSK3 pathway. Molecular Neurobiology 62 (9), 11430-11442. (2025)
• Sin R, Sotogaku N, Ohnishi YN, Shuto T, Kuroiwa M, Kawahara Y,Sugiyama K,Murakami Y, Kanai M, Funakoshi H, Chakrabotri A, Bibb JA, Nishi A: Inhibition of STAT-mediated cytokine responses to chemically-induced colotis preventsinflammation-associated neurobehavior impairments. Brain Behavior andImmunity 114, 173-186. (2023)
• Kishikawa Y, Kawahara Y, Ohnishi YN, Sotogaku N, Koeda T, Kawahara H, Nishi A: Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity. Frontiers in Pharmacology 13, 998178. (2022)
• Hashizume N, Sin R, Akiba J, Sotogaku N, Asagiri K, Hikida S, Fukahori S, Ishii S, Saikusa N, Koga Y, Egami H, Tanaka Y, Nishi A, Yagi M: The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquqporin 9 in the liver of a rat bile duct ligation model. Pediatric Surgery International 37, 1079-1088. (2021)
• Hikida T, Morita M, Kuriuwa M, Macpheson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A: Adolescent psychosocoal stress enhances sensitization to cocaine in genetically vulnerable mice. Neuroscience Research 151, 38-45. (2019)
• Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, Nishi A: Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiarty 25, 1229-1244. (2018)
• Hanada Y, Kawahara Y, Ohnishi YN, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A: p11 in cholinergic interneurons of the nucleus accumbens is essential for dopamine responses to rewarding stimuli. eNeuro 5 (5), e0332-18, 1-21. (2018)
• Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A: Chronic fluoxetine induces the enlargement of perforant path-granule cell synapses in the mouse dentate gyrus. PLos One 11 (1), e0147307. (2016)
• Yamada M, Kawahara Y, Kaneko F, Kishikawa Y, Sotogaku N, Poppinga WJ, Folgering JH, Dremencov E, Kawahara H, Nishi A: Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wister-Kyoto rats. Neuropharmacology 72, 169-178. (2013)
• Shuto T, Kuroiwa M, Koga Y, Kawahara Y, Sotogaku N, Toyomasu K, Nishi A: Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum. Neuroscience Letters 542, 107-112. (2013)
• Kuroiwa M, Hamada M, Hieda E, Shuto T, Sotogaku N, Flajolet M, Snyder GL, Hendrick JP, Fienberg A, Nishi A: Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neurophaemacology 63 (7), 1248-1257. (2012)
• Nishi A, Kuroiwa M, Miller DB, O’Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL: Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. Journal of Neuroscience 28 (42), 10460-10471. (2008)
• Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh- Wilson LC, Nishi A: Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons. Journal of Neurochemistry 103 (2), 749-766. (2007)
• Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA 3rd, Nishi A, Hsieh-Wilson LC: Sulfation petterns of glycosaminoglycans encode molecular recognition and activity. Nature Chemical Biology 2 (9), 467-473. (2006)
• Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A: Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A　receptor signaling in the neostriatum. Neuroscience 141 (1), 19-25. (2006)
• Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope BT, Fitzpatric PF, Bibb JA: Identification of tyrosine hydroxylase as a physiological substrate　for Cdk5. Journal of Neurochemistry 91 (2), 374-384. (2004)
• Takeda A, Sotogaku N, Oku N. Influence of manganese on the release of neurotransmitters in rat striatum. Brain Research 965 (1-2), 279-282. (2003)
• Takeda A, Sotogaku N, Oku N. Manganese influences the levels of neurotransmitters in synapses in rat brain. Neuroscience 114 (3), 669-674. (2002)
• Takeda A, Takatsuka K, Sotogaku N, Oku N. Influence of iron- saturation of plasma transferrin in iron distribution in the brain. Neurochemistry International 41 (4), 223-228. (2002)
• Matsumoto K, Nagashima H, Sotogaku N, Hirunuma R, Endo K. Affinity of various bio-trace elements to lipid membrane: In vivo and in vitro study using multitracer. Journal of Radioanalytical and Nuclear Chemistry 255 (3), 489-493. (2002)
• Sotogaku N, Oku N, Takeda A. Manganese concentration in mouse brain after intravenous injection. Journal of Neuroscience Research 61 (3), 350-356. (2000)
• Sotogaku N, Endo K, Hirunuma R, Enomoto S, Ambe S, Ambe F. Biochemical reactions of various trace elements with blood components and transport proteins. Journal of Radioanalytical and Nuclear Chemistry 239 (2), 429-432. (1999)
• Hirunuma R, Sotogaku N, Endo K, Enomoto S, Ambe S, Ambe F. Time dependence of distribution of radioactive trace elements in Se-deficient rats: Application of the multitracer technique. Journal of Radioanalytical and Nuclear Chemistry 239 (1), 213-215. (1999)
• Sotogaku N, Endo K, Hirunuma R, Enomoto S, Ambe S, Ambe F. Binding properties of various metals to blood components and serum proteins: a multitracer study. Journal of Trace Elements in Medicine and Biology 13 (1-2), 1-6. (1999)

【特許】

• 沈 龍佑、外角 直樹、西 昭徳：IL-1β 阻害剤（特許　第7290223号）

【E-mail】sotogaku-naoki-rn@ihwg.jp